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genetics for cannabis abuse - addiction is genetic - is addiction genetic? - impaired-cognitive genes - impaired cognition

Are Studies Linking Impaired-Cognition Genetics to Increased Risk for Cannabis Abuse Telling?

Researchers fleshed out genetic data that attempted to correlate substandard cognitive functioning with an augmented risk of cannabis abuse.¹

These researchers may not have factored in the well-established and known fact that nicotine is a top gateway drug that regularly parlays to other drug addictions, especially cannabis abuse.² Hence, the researchers may not have factored in that cannabis users, abusers, and misusers often smoked nicotine before they stated using, abusing or misusing THC, and nicotine smokers often move on to THC or add it to their feel-good-armament.

In addition, it is well known that a large percentage of cannabis abusers either were previously nicotine dependent, and/or regularly use or abuse both nicotine and cannabinoids.³

The researchers may not have considered the possibility that:

  1. Cognitive deficits such as attention deficit are very common among people with mood and anxiety problems
  2. People with attention deficit, mood and anxiety problems, frequently self-medicate with nicotine4-6
  3. Nicotine abusers often move on to cannabis abuse and dependence³
  4. People with cognitive deficits such as attention deficit, mood and anxiety problems, frequently self-medicate with cannabis
  5. There may not be genes just for cognitive dysfunction
  6. There may not be genes just for nicotine dependence
  7. There may not be genes just for cannabis dependence
  8. There may be all-in-one genes for cognitive dysfunction which obsessively compels one to self-medicate their distressing thoughts with this substance or that or those
  9. The “addiction gene” may be an intrinsic obsession to feel better by trying this drug and that, settling in on the ones that serve each person the best

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  1. Demontis D, Rajagopal VM, Thorgeirsson TE, Als TD, Grove J, et al. Genome-wide association study implicates CHRNA2 in cannabis use disorder. Nature Neuroscience, 2019; DOI: 10.1038/s41593-019-0416-1
  2. Cocores JA. Editor, The Clinical Management of Nicotine Dependence. Springer International, 1991.
  3. Dierker L, Braymiller J, Rose J, Goodwin R, Selya A. Nicotine dependence predicts cannabis use disorder symptoms among adolescents and young adults. Drug Alcohol Depend. 2018 Jun 1;187:212-220. doi: 10.1016/j.drugalcdep.2018.02.037. Epub 2018 Apr 16.
  4. Cocores JA, Varenicline and Adult ADHD. J Neuropsychiatry Clin Neurosciences, 2008
  5. Cocores JA, Transdermal Nicotine in Adult ADHD with Depression and Anxiety. Primary Care Companion J Clin Psych, 2008 10(3): 253–254
  6. Cocores JA, Varenicline and Alzheimer’s Disease. Psychiatry 2007, December, 2007



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